Comprehensive comparison of MetAP2 tissue and cellular expression pattern in lean and obese rodents.

ABSTRACT:

Background

Methionine aminopeptidase 2 (MetAP2) cleaves the initiator methionine from nascent peptides during translation. In both preclinical and clinical studies, the pharmacological inhibition of MetAP2 in obese subjects results in the suppression of food intake and body weight loss. However, the mechanism of action of body weight loss caused by MetAP2 inhibition remains to be elucidated, and the sites of action by pharmacological MetAP2 inhibition remain unknown.

Methods

In the present study, a comprehensive analysis of the MetAP2 expression pattern in mice was performed.

Results

Except for the relatively low expression in adipose tissues, MetAP2 protein was well-expressed in tissues important for metabolism, including liver, whole brain, skeletal muscle and intes

SUBMITTER: Han J 

PROVIDER: S-EPMC6167978 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature