MicroRNA-1225-5p behaves as a tumor suppressor in human glioblastoma via targeting of IRS1.

ABSTRACT:

Background

MicroRNAs (miRNAs) play an important role in cancer initiation, progression, and metastasis by directly regulating their target genes.

Materials and methods

In this study, we observed that the miR-1225-5p expression level in glioblastoma tissues was significantly lower as compared with that in normal brain tissues, and its low expression was significantly associated with histopathological grade and poor patient prognosis.

Results

Through establishing a miR-1225-5p overexpression glioblastoma cell line, we found that ectopic overexpression of miR-1225-5p inhibited the proliferation, migration, and invasion of glioblastoma cells in vitro. Moreover, the growth of a glioblastoma xenograft tumor was attenuated by overexpression of miR-1225-5p. Further integrativ

SUBMITTER: Li D 

PROVIDER: S-EPMC6167988 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature