Self-nanoemulsifying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis.

ABSTRACT:

Background

Bruceine D (BD) is a major bioactive component isolated from the traditional Chinese medicinal plant Brucea javanica which has been widely utilized to treat dysentery (also known as ulcerative colitis [UC]).

Methods

To improve the water solubility and absolute bioavailability of BD, we developed a self-nanoemulsifying drug delivery system (SNEDDS) composing of MCT (oil), Solutol HS-15 (surfactant), propylene glycol (co-surfactant) and BD. The physicochemical properties and pharmacokinetics of BD-SNEDDS were characterized, and its anti-UC activity and potential mechanism were evaluated in TNBS-induced UC rat model.

Results

The prepared nanoemulsion has multiple beneficial aspects including small mean droplet size, low polydispersity index (PDI), high

SUBMITTER: Dou YX 

PROVIDER: S-EPMC6167998 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature