Fluorescence properties of curcumin-loaded nanoparticles for cell tracking.

ABSTRACT:

Background

Posttransplant cell tracking, via stem cell labeling, is a crucial strategy for monitoring and maximizing benefits of cell-based therapies. The structures and functionalities of polysaccharides, proteins, and lipids allow their utilization in nanotechnology systems.

Materials and methods

In the present study, we analyzed the potential benefit of curcumin-loaded nanoparticles (NPC) using Vero cells (in vitro) and NPC-labeled adipose-derived mesenchymal stem cells (NPC-ADMSCs) (in vivo) in myocardial infarction and sciatic nerve crush preclinical models. Thereafter, transplantation, histological examination, real time imaging, and assessment of tissue regeneration were done.

Results

Transplanted NPC-ADMSCs were clearly identified and revealed potential benefi

SUBMITTER: Mogharbel BF 

PROVIDER: S-EPMC6168007 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature