FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials.

ABSTRACT:

Objective

 To assess the effect of the FTO genotype on weight loss after dietary, physical activity, or drug based interventions in randomised controlled trials.

Design

 Systematic review and random effects meta-analysis of individual participant data from randomised controlled trials.

Data sources

 Ovid Medline, Scopus, Embase, and Cochrane from inception to November 2015.

Eligibility criteria for study selection

 Randomised controlled trials in overweight or obese adults reporting reduction in body mass index, body weight, or waist circumference by FTO genotype (rs9939609 or a proxy) after dietary, physical activity, or drug based interventions. Gene by treatment interaction models were fitted to individual participant data from all studies included in this r

SUBMITTER: Livingstone KM 

PROVIDER: S-EPMC6168036 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature