Network, Transcriptomic and Genomic Features Differentiate Genes Relevant for Drug Response.

ABSTRACT: Understanding the mechanisms underlying drug therapeutic action and toxicity is crucial for the prevention and management of drug adverse reactions, and paves the way for a more efficient and rational drug design. The characterization of drug targets, drug metabolism proteins, and proteins associated to side effects according to their expression patterns, their tolerance to genomic variation and their role in cellular networks, is a necessary step in this direction. In this contribution, we hypothesize that different classes of proteins involved in the therapeutic effect of drugs and in their adverse effects have distinctive transcriptomics, genomics and network features. We explored the properties of these proteins within global and organ-specific interactomes, using multi-scale network f

SUBMITTER: Pinero J 

PROVIDER: S-EPMC6168038 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature