Regulatory T cells antagonize proinflammatory response of IL-17 during cutaneous tuberculosis.

ABSTRACT:

Background

The clinical forms of cutaneous tuberculosis (CTB) consist of a spectrum that reflects the host's immune response to Mycobacterium tuberculosis; it provides an ideal model to study the immunological dysregulation in humans. IL-17 plays an important role in initial immune response and is involved in both immune-mediated protection and pathology during M. tuberculosis infection. TGF-β producing regulatory T-cells (Tregs) are high in leprosy patients and responsible for immune suppression. However, in CTB, the involvement of Tregs and Th17 remains unevaluated.

Objective

To study the role of proinflammatory Th17 and Treg cells in the human CTB.

Methods

Blood and skin biopsies of CTB patients and healthy controls (HC) were included in the study. Fl

SUBMITTER: Saini C 

PROVIDER: S-EPMC6168067 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature