Determining the molecular basis of voltage sensitivity in membrane proteins.

ABSTRACT: Voltage-sensitive membrane proteins are united by their ability to transform changes in membrane potential into mechanical work. They are responsible for a spectrum of physiological processes in living organisms, including electrical signaling and cell-cycle progression. Although the mechanism of voltage-sensing has been well characterized for some membrane proteins, including voltage-gated ion channels, even the location of the voltage-sensing elements remains unknown for others. Moreover, the detection of these elements by using experimental techniques is challenging because of the diversity of membrane proteins. Here, we provide a computational approach to predict voltage-sensing elements in any membrane protein, independent of its structure or function. It relies on an estimation of th

SUBMITTER: Kasimova MA 

PROVIDER: S-EPMC6168238 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature