Haemodilution and head-down tilting induce functional injury in the rat optic nerve: A model for peri-operative ischemic optic neuropathy.

ABSTRACT:

Background

Mechanisms of peri-operative ischaemic optic neuropathy remain poorly understood. Both specific pre-operative and intra-operative factors have been examined by retrospective studies, but no animal model currently exists.

Objectives

To develop a rodent model of peri-operative ischaemic optic neuropathy. In rats, we performed head-down tilt and/or haemodilution, theorising that the combination damages the optic nerve.

Design

Animal study.

Setting

Laboratory.

Animals

A total of 36 rats, in four groups, completed the functional examination of retina and optic nerve after the interventions.

Interventions

Anaesthetised groups (n>8) were supine (SUP) for 5 h, head-down tilted 70° for 5 h, head-down tilted/haemodiluted for 5 h or SUP/haemodilut

SUBMITTER: Roth S 

PROVIDER: S-EPMC6168371 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature