A genetic perspective on the relationship between eudaimonic -and hedonic well-being.

ABSTRACT: Whether hedonism or eudaimonia are two distinguishable forms of well-being is a topic of ongoing debate. To shed light on the relation between the two, large-scale available molecular genetic data were leveraged to gain more insight into the genetic architecture of the overlap between hedonic and eudaimonic well-being. Hence, we conducted the first genome-wide association studies (GWAS) of eudaimonic well-being (N = ~108 K) and linked it to a GWAS of hedonic well-being (N = ~222 K). We identified the first two genome-wide significant independent loci for eudaimonic well-being and six independent loci for hedonic well-being. Joint analyses revealed a moderate phenotypic correlation (r = 0.53) and a high genetic correlation (r_g = 0.78) between eudaimonic and hedonic well-being. Th

SUBMITTER: Baselmans BML 

PROVIDER: S-EPMC6168466 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature