Sin3A recruits Tet1 to the PAH1 domain via a highly conserved Sin3-Interaction Domain.

ABSTRACT: The Sin3A complex acts as a transcriptional hub, integrating the function of diverse transcription factors with histone modifying enzymes, notably, histone deacetylases (HDAC) 1 and 2. The Sin3A protein sits at the centre of the complex, mediating multiple simultaneous protein-protein interactions via its four paired-amphipathic helix (PAH) domains (PAH1-4). The PAH domains contain a conserved four helical bundle, generating a hydrophobic cleft into which the single-helix of a Sin3-interaction domain (SID) is able to insert and bind with high affinity. Although they share a similar mode of interaction, the SIDs of different repressor proteins bind to only one of four potential PAH domains, due to the specific combination of hydrophobic residues at the interface. Here we report the identifi

SUBMITTER: Chandru A 

PROVIDER: S-EPMC6168491 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature