Development of multi-layered and multi-sensitive polymeric nanocontainers for cancer therapy: in vitro evaluation.

ABSTRACT: Nanoscale drug delivery systems represent a promising strategy to treat cancer and to overcome the side effects of chemotherapy. In particular, hollow polymeric nanocontainers have attracted great interest because of their structural and morphological advantages and the variety of polymers that can be used, allowing the synthesis of stimuli-responsive materials capable of responding to the biochemical alterations of the tumour microenvironment. Here are reported the synthesis, characterization and in vitro evaluation of a three-stimuli-sensitive hollow nanocontainer consisting of three different shells, each one sensitive to a specific tumoral stimulus: in order pH, temperature and reducing environment. To test its properties, daunorubicin was used as a model drug, for which the nanocontai

SUBMITTER: Toniolo G 

PROVIDER: S-EPMC6168533 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature