The Role of p53 in Determining Mitochondrial Adaptations to Endurance Training in Skeletal Muscle.

ABSTRACT: p53 plays an important role in regulating mitochondrial homeostasis. However, it is unknown whether p53 is required for the physiological and mitochondrial adaptations with exercise training. Furthermore, it is also unknown whether impairments in the absence of p53 are a result of its loss in skeletal muscle, or a secondary effect due to its deletion in alternative tissues. Thus, we investigated the role of p53 in regulating mitochondria both basally, and under the influence of exercise, by subjecting C57Bl/6J whole-body (WB) and muscle-specific p53 knockout (mKO) mice to a 6-week training program. Our results confirm that p53 is important for regulating mitochondrial content and function, as well as proteins within the autophagy and apoptosis pathways. Despite an increased proportion of p

SUBMITTER: Beyfuss K 

PROVIDER: S-EPMC6168598 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature