Effects of Metabolic Energy on Synaptic Transmission and Dendritic Integration in Pyramidal Neurons.

ABSTRACT: As a sophisticated computing unit, the pyramidal neuron requires sufficient metabolic energy to fuel its powerful computational capabilities. However, the majority of previous works focus on nonlinear integration and energy consumption in individual pyramidal neurons but seldom on the effects of metabolic energy on synaptic transmission and dendritic integration. Here, we developed biologically plausible models to simulate the synaptic transmission and dendritic integration of pyramidal neurons, exploring the relations between synaptic transmission and metabolic energy and between dendritic integration and metabolic energy. We find that synaptic energy not only drives synaptic vesicle cycle, but also participates in the regulation of this cycle. Release probability of synapses adapts to sy

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC6168642 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature