Early Everolimus Initiation Fails to Counteract the Cytotoxic Response Mediated by CD8⁺ T and NK Cells in Heart Transplant Patients.

ABSTRACT: The positive long-term effects of conversion to everolimus (EVL) after heart transplantation (HT) have been evaluated in several studies. However, the timing of EVL initiation, the best way to combine it with other immunosuppressive treatments, and the impact of these combinations on the immune response are poorly understood aspects. Here, we analyzed the immune phenotype and function of HT patients (n = 56) at short and long terms (prospective and retrospective cohorts), taking into account the time of EVL initiation: early (3 months post-transplant, EVL-E group) or late (>1 year post-transplant, EVL-L group) compared with mycophenolate mofetil treatment (MMF group). We show that early EVL conversion from MMF allows the increase of cytotoxic (CD56^dim CD16⁺) NK

SUBMITTER: Diaz-Molina B 

PROVIDER: S-EPMC6168668 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature