Acute Myeloid Leukemia Cells Express ICOS Ligand to Promote the Expansion of Regulatory T Cells.

ABSTRACT: CD4⁺CD25⁺Foxp3⁺ regulatory T cells (Tregs) accumulate in bone marrow microenvironment in acute myeloid leukemia (AML). However, little is known about how the tumor environment including tumor cells themselves affects this process. Here we demonstrated that AML cells expressed inducible T-cell costimulator ligand (ICOSL) that can provide costimulation through ICOS for the conversion and expansion of Tregs sustaining high Foxp3 and CD25 expression as well as a suppressive function. TNF-a stimulation up-regulated the expression of ICOSL. Furthermore, both the conversion and expansion of CD4⁺CD25⁺Foxp3⁺ T cells and CD4⁺ICOS⁺Foxp3⁺ T cells were induced by co-culture with AML cells overexpressed IC

SUBMITTER: Han Y 

PROVIDER: S-EPMC6168677 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature