Crocin exerts anti-inflammatory and anti-arthritic effects on type II collagen-induced arthritis in rats.

ABSTRACT:

Context

Rheumatoid arthritis (RA) is a common systemic auto-immune disease, which is characterized by chronic and symmetry synovial inflammation. Crocin has been reported to exhibit anti-inflammatory effects in animal models.

Objective

This study investigates the anti-inflammatory and anti-arthritic effects of crocin on type II collagen-induced arthritis (CIA) in Wistar rats.

Materials and methods

The CIA rat model was established and randomly divided into five groups with or without crocin treatment (10, 20 or 40 mg/kg), which was started on day 21 after arthritis induction and persisted for 36 days. The symptoms and molecular mechanisms of CIA and crocin-treated CIA rats were compared and investigated.

Results

CIA rats presented severe RA symptoms, including

SUBMITTER: Liu W 

PROVIDER: S-EPMC6168764 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature