Comparative structure analysis of the ETSi domain of ERG3 and its complex with the E74 promoter DNA sequence.

ABSTRACT: ERG3 (ETS-related gene) is a member of the ETS (erythroblast transformation-specific) family of transcription factors, which contain a highly conserved DNA-binding domain. The ETS family of transcription factors differ in their binding to promoter DNA sequences, and the mechanism of their DNA-sequence discrimination is little known. In the current study, crystals of the ETSi domain (the ETS domain of ERG3 containing a CID motif) in space group P4₁2₁2 and of its complex with the E74 DNA sequence (DNA₉) in space group C222₁ were obtained and their structures were determined. Comparative structure analysis of the ETSi domain and its complex with DNA₉ with previously determined structures of the ERGi domain (the ETS domain of ERG containin

SUBMITTER: Sharma R 

PROVIDER: S-EPMC6168766 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature