Distinct Gene Expression Profiles Define Anaplastic Grade in Retinoblastoma.

ABSTRACT: Morbidity and mortality associated with retinoblastoma have decreased drastically in recent decades, in large part owing to better prediction of high-risk disease and appropriate treatment stratification. High-risk histopathologic features and severe anaplasia both predict the need for more aggressive treatment; however, not all centers are able to assess tumor samples easily for the degree of anaplasia. Instead, identification of genetic signatures that are able to distinguish among anaplastic grades and thus predict high- versus low-risk retinoblastoma would facilitate appropriate risk stratification in a wider patient population. A better understanding of genes dysregulated in anaplasia also would yield valuable insights into pathways underlying the development of more severe retinoblas

SUBMITTER: Hudson LE 

PROVIDER: S-EPMC6168968 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature