Postmenopausal weight change and incidence of fracture: post hoc findings from Women's Health Initiative Observational Study and Clinical Trials.

ABSTRACT:

Objectives

To determine associations between postmenopausal change in body weight and incidence of fracture and associations between voluntary and involuntary weight loss and risk of fracture.

Design

Post hoc analysis of data from the Women's Health Initiative Observational Study and Clinical Trials.

Setting

40 clinical centers in the United States.

Participants

120,566 postmenopausal women, aged 50-79 at baseline (1993-98), followed through 2013 (mean fracture follow-up duration 11 years from baseline).

Exposures

Annualized percentage change in measured body weight from baseline to year 3, classified as stable (<5% change), weight loss (≥ 5%), or weight gain (≥ 5%). Self assessment of whether weight loss was intentional or unintentional. Cox proportiona

SUBMITTER: Crandall CJ 

PROVIDER: S-EPMC6168976 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature