An Ex Vivo Vessel Injury Model to Study Remodeling.

ABSTRACT:

Objective

Invasive coronary interventions can fail due to intimal hyperplasia and restenosis. Endothelial cell (EC) seeding to the vessel lumen, accelerating re-endothelialization, or local release of mTOR pathway inhibitors have helped reduce intimal hyperplasia after vessel injury. While animal models are powerful tools, they are complex and expensive, and not always reflective of human physiology. Therefore, we developed an in vitro 3D vascular model validating previous in vivo animal models and utilizing isolated human arteries to study vascular remodeling after injury.

Approach

We utilized a bioreactor that enables the control of intramural pressure and shear stress in vessel conduits to investigate the vascular response in both rat and human arteries to intraluminal in

SUBMITTER: Kural MH 

PROVIDER: S-EPMC6168986 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature