FGF2 Enhances Odontoblast Differentiation by αSMA⁺ Progenitors In Vivo.

ABSTRACT: The goal of this study was to examine the effects of early and limited exposure of perivascular cells expressing α (αSMA) to fibroblast growth factor 2 (FGF2) in vivo. We performed in vivo fate mapping by inducible Cre-loxP and experimental pulp injury in molars to induce reparative dentinogenesis. Our results demonstrate that early delivery of exogenous FGF2 to exposed pulp led to proliferative expansion of αSMA-tdTomato⁺ cells and their accelerated differentiation into odontoblasts. In vivo lineage-tracing experiments showed that the calcified bridge/reparative dentin in FGF2-treated pulps were lined with an increased number of Dspp⁺ odontoblasts and devoid of BSP⁺ osteoblasts. The increased number of odontoblasts derived from αSMA-tdTomato⁺ ce

SUBMITTER: Vidovic-Zdrilic I 

PROVIDER: S-EPMC6169028 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature