Bioengineered Tooth Buds Exhibit Features of Natural Tooth Buds.

ABSTRACT: Tooth loss is a significant health issue currently affecting millions of people worldwide. Artificial dental implants, the current gold standard tooth replacement therapy, do not exhibit many properties of natural teeth and can be associated with complications leading to implant failure. Here we propose bioengineered tooth buds as a superior alternative tooth replacement therapy. We describe improved methods to create highly cellularized bioengineered tooth bud constructs that formed hallmark features that resemble natural tooth buds such as the dental epithelial stem cell niche, enamel knot signaling centers, transient amplifying cells, and mineralized dental tissue formation. These constructs were composed of postnatal dental cells encapsulated within a hydrogel material that were implan

SUBMITTER: Smith EE 

PROVIDER: S-EPMC6169029 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature