Association of proton pump inhibitors with the risk of hepatic encephalopathy during hospitalization for liver cirrhosis.

ABSTRACT:

Background

Hepatic encephalopathy is associated with altered gut microbiota. Proton pump inhibitors increase the risk of small bowel bacterial overgrowth.

Objectives

This was a case-control study aimed at exploring the relationship of proton pump inhibitor use with the risk of hepatic encephalopathy during hospitalization in liver cirrhosis.

Methods

Case and control groups were defined as cirrhotic patients who developed hepatic encephalopathy during hospitalization and those without hepatic encephalopathy at admission or during hospitalization, respectively. Age, gender, and Child-Pugh score were matched between the groups. Odds ratios with 95% confidence intervals were calculated to express the association of proton pump inhibitors with the risk of hepatic encephalo

SUBMITTER: Zhu J 

PROVIDER: S-EPMC6169047 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature