Is impaired information processing speed a matter of structural or functional damage in MS?

ABSTRACT:

Objective

Cognitive deficits, especially those of information processing speed (IPS), are common in multiple sclerosis (MS), however, the underlying neurobiological mechanisms remain poorly understood. In this study, we examined structural and functional brain changes separately, but also in an integrative manner, in relation to IPS performance.

Methods

IPS was measured using the symbol digit modalities test (SDMT) in 330 MS patients and 96 controls. Patients with IPS impairment (IPS-I, z-score < -1.5) were compared to patients with preserved IPS performance (IPS-P) on volumetric measures, white matter integrity loss (using diffusion tensor imaging) and the severity of functional connectivity changes (using resting-state fMRI). Significant predictors of IPS performance were

SUBMITTER: Meijer KA 

PROVIDER: S-EPMC6169100 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature