Ontology highlight
ABSTRACT:
SUBMITTER: Numata S
PROVIDER: S-EPMC6169204 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Numata Shusuke S Umehara Hidehiro H Ohmori Tetsuro T Hashimoto Ryota R
Frontiers in pharmacology 20180926
Clozapine is an efficacious atypical antipsychotic for treatment-refractory schizophrenia. Clinical response and appearance of adverse events vary among individual patients receiving clozapine, with genetic and non-genetic factors potentially contributing to individual variabilities. Pharmacogenetic studies investigate associations between genetic variants and drug efficacy and toxicity. To date, most pharmacogenetic studies of clozapine have been conducted through candidate gene approaches. A r ...[more]