Revealing aperiodic aspects of solenoid proteins from sequence information.

ABSTRACT:

Motivation

Repeat proteins, which contain multiple repeats of short sequence motifs, form a large but seldom-studied group of proteins. Methods focusing on the analysis of 3D structures of such proteins identified many subtle effects in length distribution of individual motifs that are important for their functions. However, similar analysis was yet not applied to the vast majority of repeat proteins with unknown 3D structures, mostly because of the extreme diversity of the underlying motifs and the resulting difficulty to detect those.

Results

We developed FAIT, a sequence-based algorithm for the precise assignment of individual repeats in repeat proteins and introduced a framework to classify and compare aperiodicity patterns for large protein families. FAIT extracts repea

SUBMITTER: Hrabe T 

PROVIDER: S-EPMC6169467 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature