Formation and phenotypic characterization of CD49a, CD49b and CD103 expressing CD8 T cell populations in human metastatic melanoma.

ABSTRACT: Integrins α1β1 (CD49a), α2β1 (CD49b) and αEβ7 (CD103) mediate retention of lymphocytes in peripheral tissues, and their expression is upregulated on tumor infiltrating lymphocytes (TIL) compared to circulating lymphocytes. Little is known about what induces expression of these retention integrins (RI) nor whether RI define subsets in the tumor microenvironment (TME) with a specific phenotype. Human metastatic melanoma-derived CD8 TIL could be grouped into five subpopulations based on RI expression patterns: RI^neg, CD49a⁺ only, CD49a⁺CD49b⁺, CD49a⁺CD103⁺, or positive for all three RI. A significantly larger fraction of the CD49a⁺ only subpopulation expressed multiple effector cytokines, whereas CD49a⁺CD1

SUBMITTER: Melssen MM 

PROVIDER: S-EPMC6169593 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature