TRPS1 regulates oestrogen receptor binding and histone acetylation at enhancers.

ABSTRACT: The chromatin state is finely tuned to regulate function and specificity for transcription factors such as oestrogen receptor alpha (ER), which contributes to cell growth in breast cancer. ER transcriptional potential is mediated, in large part, by the specific associated proteins and co-factors that interact with it. Despite the identification and characterisation of several ER coregulators, a complete and systematic view of ER-regulating chromatin modifiers is lacking. By exploiting a focused siRNA screen that investigated the requirement for a library of 330 chromatin regulators in ER-mediated cell growth, we find that the NuRD and coREST histone deacetylation complexes are critical for breast cancer cell proliferation. Further, by proteomic and genomics approaches, we discover the tran

SUBMITTER: Serandour AA 

PROVIDER: S-EPMC6169732 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature