A possible approach to improving the reproducibility of urinary concentrations of phthalate metabolites and phenols during pregnancy.

ABSTRACT: In epidemiologic studies, classifying episodic exposures to chemicals with short half-lives, such as phthalates and phenols, is challenging. We assessed whether accounting for sources of variability unrelated to exposure pathways would improve the reproducibility of urine concentrations of select phthalate metabolites and phenols. In 2011, a subset of pregnant women (n = 19) enrolled in a prospective study provided first morning urine samples every 3-4 weeks between 16 and 36 weeks gestation. At the time of collection, we identified potential contributors to variations in urinary concentrations: weight gain, gestational age, time slept, time since awoke, time since last food/drink, and time since last void. We estimated intraclass correlation coefficients (ICCs) among repeat urine concentr

SUBMITTER: Yazdy MM 

PROVIDER: S-EPMC6170163 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature