Piezo1 and G_q/G₁₁ promote endothelial inflammation depending on flow pattern and integrin activation.

ABSTRACT: The vascular endothelium is constantly exposed to mechanical forces, including fluid shear stress exerted by the flowing blood. Endothelial cells can sense different flow patterns and convert the mechanical signal of laminar flow into atheroprotective signals, including eNOS activation, whereas disturbed flow in atheroprone areas induces inflammatory signaling, including NF-κB activation. How endothelial cells distinguish different flow patterns is poorly understood. Here we show that both laminar and disturbed flow activate the same initial pathway involving the mechanosensitive cation channel Piezo1, the purinergic P2Y₂ receptor, and G_q/G₁₁-mediated signaling. However, only disturbed flow leads to Piezo1- and G_q/G₁₁-mediated integrin

SUBMITTER: Albarran-Juarez J 

PROVIDER: S-EPMC6170174 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature