MnO₂-gated Nanoplatforms with Targeted Controlled Drug Release and Contrast-Enhanced MRI Properties: from 2D Cell Culture to 3D Biomimetic Hydrogels.

ABSTRACT: Multifunctional nanomaterials combining diagnosis and therapeutic properties have attracted a considerable attention in cancer research. Yet some important challenges are still to be faced, including an optimal coupling between these two types of properties that would be effective within complex biological tissues. To address these points, we have prepared novel nanoplatforms associating controlled drug delivery of doxorubicin and Magnetic Resonance Imaging (MRI) contrast-enhancement that exhibit high specificity towards cancer cells compared to normal cells and evaluated them both in 2D cultures and within 3D tissue-like biomimetic matrices.

Methods

Nanoplatforms were prepared from hollow silica nanoparticles coated with MnO₂ nanosheets and conjugated with the AS1411 apt

SUBMITTER: Shi Y 

PROVIDER: S-EPMC6170331 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature