Human serum albumin alters specific genes that can play a role in survival and persistence in Acinetobacter baumannii.

ABSTRACT: In the past few decades Acinetobacter baumannii has emerged as a notorious nosocomial pathogen because of its ability to acquire genetic material and persist in extreme environments. Recently, human serum albumin (HSA) was shown to significantly increase natural transformation frequency in A. baumannii. This observation led us to perform transcriptomic analysis of strain A118 under HSA induction to identify genes that are altered by HSA. Our results revealed the statistically significant differential expression of 296 protein-coding genes, including those associated with motility, biofilm formation, metabolism, efflux pumps, capsule synthesis, and transcriptional regulation. Phenotypic analysis of these traits showed an increase in surface-associated motility, a decrease in biofilm formati

SUBMITTER: Quinn B 

PROVIDER: S-EPMC6170387 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature