Structure of the intact 14-subunit human cytochrome c oxidase.

ABSTRACT: Respiration is one of the most basic features of living organisms, and the electron transport chain complexes are probably the most complicated protein system in mitochondria. Complex-IV is the terminal enzyme of the electron transport chain, existing either as randomly scattered complexes or as a component of supercomplexes. NDUFA4 was previously assumed as a subunit of complex-I, but recent biochemical data suggested it may be a subunit of complex-IV. However, no structural evidence supporting this notion was available till now. Here we obtained the 3.3 Å resolution structure of complex-IV derived from the human supercomplex I₁III₂IV₁ and assigned the NDUFA4 subunit into complex-IV. Intriguingly, NDUFA4 lies exactly at the dimeric interface observed in pr

SUBMITTER: Zong S 

PROVIDER: S-EPMC6170408 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature