Caloric restriction promotes functional changes involving short-chain fatty acid biosynthesis in the rat gut microbiota.

ABSTRACT: Caloric restriction (CR) is known to promote health and longevity, likely via modification of the gut microbiota (GM). However, functional and metabolic changes induced in the GM during CR are still unidentified. Here, we investigated the short- and long-term effects of CR on the rat GM using a metaproteogenomic approach. We show that a switch from ad libitum (AL) low fat diet to CR in young rats is able to induce rapid and deep changes in their GM metaproteomic profile, related to a reduction of the Firmicutes/Bacteroidetes ratio and an expansion of lactobacilli. Specifically, we observed a significant change in the expression of the microbial enzymes responsible for short-chain fatty acid biosynthesis, with CR boosting propionogenesis and limiting butyrogenesis and acetogenesis. Furtherm

SUBMITTER: Tanca A 

PROVIDER: S-EPMC6170429 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature