Kidney-derived c-kit⁺ progenitor/stem cells contribute to podocyte recovery in a model of acute proteinuria.

ABSTRACT: Kidney-derived c-kit⁺ cells exhibit progenitor/stem cell properties and can regenerate epithelial tubular cells following ischemia-reperfusion injury in rats. We therefore investigated whether c-kit⁺ progenitor/stem cells contribute to podocyte repair in a rat model of acute proteinuria induced by puromycin aminonucleoside (PAN), the experimental prototype of human minimal change disease and early stages of focal and segmental glomerulosclerosis. We found that c-kit⁺ progenitor/stem cells accelerated kidney recovery by improving foot process effacement (foot process width was lower in c-kit group vs saline treated animals, P = 0.03). In particular, these cells engrafted in small quantity into tubules, vessels, and glomeruli, where they occasionally differen

SUBMITTER: Rangel EB 

PROVIDER: S-EPMC6170432 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature