Feasibility and robustness of dynamic ¹⁸F-FET PET based tracer kinetic models applied to patients with recurrent high-grade glioma prior to carbon ion irradiation.

ABSTRACT: The aim of this study was to analyze the robustness and diagnostic value of different compartment models for dynamic ¹⁸F-FET PET in recurrent high-grade glioma (HGG). Dynamic ¹⁸F-FET PET data of patients with recurrent WHO grade III (n:7) and WHO grade IV (n: 9) tumors undergoing re-irradiation with carbon ions were analyzed by voxelwise fitting of the time-activity curves with a simplified and an extended one-tissue compartment model (1TCM) and a two-tissue compartment model (2TCM), respectively. A simulation study was conducted to assess robustness and precision of the 2TCM. Parameter maps showed enhanced detail on tumor substructure. Neglecting the blood volume V_B in the 1TCM yields insufficient results. Parameter K₁ from both 1TCM and 2TCM sh

SUBMITTER: Debus C 

PROVIDER: S-EPMC6170489 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature