The histone demethylase KDM6B in the medial prefrontal cortex epigenetically regulates cocaine reward memory.

ABSTRACT: Epigenetic remodeling contributes to synaptic plasticity via modification of gene expression, which underlies cocaine-induced long-term memory. A prevailing hypothesis in drug addiction is that drugs of abuse rejuvenate developmental machinery to render reward circuitry highly plastic and thus engender drug memories to be highly stable. Identification and reversal of these pathological pathways are therefore critical for cocaine abuse treatment. Previous studies revealed an interesting finding in which the mRNA of histone lysine demethylase, KDM6B, is upregulated in the medial prefrontal cortex (mPFC) during early cocaine withdrawal. However, whether and how it contributes to drug-seeking behavior remain unknown. Here we used a conditioned place preference paradigm to investigate the poten

SUBMITTER: Zhang YX 

PROVIDER: S-EPMC6170674 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature