Interleukin-1 Receptor Antagonist Is Associated With Pediatric Acute Respiratory Distress Syndrome and Worse Outcomes in Children With Acute Respiratory Failure.

ABSTRACT:

Objectives

To test whether plasma interleukin-1 receptor antagonist or variants within the gene encoding for interleukin-1ra (IL1RN), or proteins involved in regulating interleukin-1β levels or interleukin-1β response, are associated with pediatric acute respiratory distress syndrome or outcomes in mechanically ventilated children with parenchymal lung disease.

Design

Prospective cohort study.

Setting

Twenty-two PICUs participating in the multisite clinical trial, Randomized Evaluation of Sedation Titration for Respiratory Failure (U01 HL086622).

Subjects

Children 2 weeks to 17 years old treated with invasive mechanical ventilation for acute airways and/or parenchymal lung disease.

Measurements and main results

Three-hundred seventy-eight of 549 patients

SUBMITTER: Dahmer MK 

PROVIDER: S-EPMC6170680 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature