Carotid artery atherosclerosis is associated with mortality in HIV-positive women and men.

ABSTRACT:

Objective

Among people with HIV, there are few long-term studies of noninvasive ultrasound-based measurements of the carotid artery predicting major health events. We hypothesized that such measurements are associated with 10-year mortality in the Women's Interagency HIV Study (WIHS) and Multicenter AIDS Cohort Study (MACS), and that associations differ by HIV serostatus.

Design

Nested cohort study.

Methods

Participants without coronary heart disease underwent B-mode carotid artery ultrasound, with measurement of common carotid artery intima-media thickness (IMT); carotid artery plaque (focal IMT > 1.5 mm) at six locations; and Young's modulus of elasticity, a measure of arterial stiffness. We examined all-cause mortality using Cox models, controlling for demographic,

SUBMITTER: Hanna DB 

PROVIDER: S-EPMC6170701 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature