Accounting for residence-time in blood rheology models: do we really need non-Newtonian blood flow modelling in large arteries?

ABSTRACT: Patient-specific computational fluid dynamics (CFD) is a promising tool that provides highly resolved haemodynamics information. The choice of blood rheology is an assumption in CFD models that has been subject to extensive debate. Blood is known to exhibit shear-thinning behaviour, and non-Newtonian modelling has been recommended for aneurysmal flows. Current non-Newtonian models ignore rouleaux formation, which is the key player in blood's shear-thinning behaviour. Experimental data suggest that red blood cell aggregation and rouleaux formation require notable red blood cell residence-time (RT) in a low shear rate regime. This study proposes a novel hybrid Newtonian and non-Newtonian rheology model where the shear-thinning behaviour is activated in high RT regions based on experimental d

SUBMITTER: Arzani A 

PROVIDER: S-EPMC6170779 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature