Cell-resolved blood flow simulations of saccular aneurysms: effects of pulsatility and aspect ratio.

ABSTRACT: We study the effect of pulsatile flow on the transport of red blood cells (RBCs) and platelets into aneurysm geometries with varying dome-to-neck aspect ratios (AR). We use a validated two-dimensional lattice Boltzmann model for blood plasma with a discrete element method for both RBCs and platelets coupled by the immersed boundary method. Flow velocities and vessel diameters were matched with measurements of cerebral perforating arteries and flow was driven by a synthetic heartbeat curve typical for such vessel sizes. We observe a flow regime change as the aspect ratio increases from a momentum-driven regime in the small aspect ratio to a shear-driven regime in the larger aspect ratios. In the small aspect ratio case, we see the development of a re-circulation zone that exhibits a layerin

SUBMITTER: Czaja B 

PROVIDER: S-EPMC6170784 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature