Control of seminal fluid protein expression via regulatory hubs in <i>Drosophila melanogaster</i>.

ABSTRACT: Highly precise, yet flexible and responsive coordination of expression across groups of genes underpins the integrity of many vital functions. However, our understanding of gene regulatory networks (GRNs) is often hampered by the lack of experimentally tractable systems, by significant computational challenges derived from the large number of genes involved or from difficulties in the accurate identification and characterization of gene interactions. Here we used a tractable experimental system in which to study GRNs: the genes encoding the seminal fluid proteins that are transferred along with sperm (the 'transferome') in Drosophila melanogaster fruit flies. The products of transferome genes are core determinants of reproductive success and, to date, only transcription factors have

SUBMITTER: Mohorianu I 

PROVIDER: S-EPMC6170815 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature