Microfluidic spinning of the fibrous alginate scaffolds for modulation of the degradation profile.

ABSTRACT: In tissue engineering, alginate has been an attractive material due to its biocompatibility and ability to form hydrogels, unless its uncontrollable degradation could be an undesirable feature. Here, we developed a simple and easy method to tune the degradation profile of the fibrous alginate scaffolds by the microfluidic wet spinning techniques, according with the use of isopropyl alcohol for dense packing of alginate chains in the microfiber production and the increase of crosslinking with Ca²⁺ ion. The degradation profiling was analyzed by mass losses, swelling ratios, and also observation of the morphologic changes. The results demonstrated that high packing density might be provided by self-aggregation of polymer chains through high dipole interactions between sheath and co

SUBMITTER: Mun CH 

PROVIDER: S-EPMC6170856 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature