Voltage-Gated Calcium Channels: Key Players in Sensory Coding in the Retina and the Inner Ear.

ABSTRACT: Calcium influx through voltage-gated Ca (Ca_V) channels is the first step in synaptic transmission. This review concerns Ca_V channels at ribbon synapses in primary sense organs and their specialization for efficient coding of stimuli in the physical environment. Specifically, we describe molecular, biochemical, and biophysical properties of the Ca_V channels in sensory receptor cells of the retina, cochlea, and vestibular apparatus, and we consider how such properties might change over the course of development and contribute to synaptic plasticity. We pay particular attention to factors affecting the spatial arrangement of Ca_V channels at presynaptic, ribbon-type active zones, because the spatial relationship between Ca_V channels and re

SUBMITTER: Pangrsic T 

PROVIDER: S-EPMC6170976 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature