Combining controls can improve power in two-stage association studies.

ABSTRACT:

Background

High dimensional case control studies are ubiquitous in the biological sciences, particularly genomics. To maximise power while constraining cost and to minimise type-1 error rates, researchers typically seek to replicate findings in a second experiment on independent cohorts before proceeding with further analyses. This can be an expensive procedure, particularly when control samples are difficult to recruit or ascertain; for example in inter-disease comparisons, or studies on degenerative diseases.

Results

This paper presents a method in which control (or case) samples from the discovery cohort are re-used in a replication study. The theoretical implications of this method are discussed and simulated genome-wide association study (GWAS) tests are used to compare

SUBMITTER: Liley J 

PROVIDER: S-EPMC6171163 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature