Genetic Variants Associated with Circulating Fibroblast Growth Factor 23.

ABSTRACT:

Background

Fibroblast growth factor 23 (FGF23), a bone-derived hormone that regulates phosphorus and vitamin D metabolism, contributes to the pathogenesis of mineral and bone disorders in CKD and is an emerging cardiovascular risk factor. Central elements of FGF23 regulation remain incompletely understood; genetic variation may help explain interindividual differences.

Methods

We performed a meta-analysis of genome-wide association studies of circulating FGF23 concentrations among 16,624 participants of European ancestry from seven cohort studies, excluding participants with eGFR<30 ml/min per 1.73 m² to focus on FGF23 under normal conditions. We evaluated the association of single-nucleotide polymorphisms (SNPs) with natural log-transformed FGF23 concentration, a

SUBMITTER: Robinson-Cohen C 

PROVIDER: S-EPMC6171267 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature