MicroRNA-214-3p in the Kidney Contributes to the Development of Hypertension.

ABSTRACT:

Background

In spite of extensive study, the mechanisms for salt sensitivity of BP in humans and rodent models remain poorly understood. Several microRNAs (miRNAs) have been associated with hypertension, but few have been shown to contribute to its development.

Methods

We examined miRNA expression profiles in human kidney biopsy samples and rat models using small RNA deep sequencing. To inhibit an miRNA specifically in the kidney in conscious, freely moving rats, we placed indwelling catheters to allow both renal interstitial administration of a specific anti-miR and measurement of BP. A rat with heterozygous disruption of the gene encoding endothelial nitric oxide synthase (eNOS) was developed. We used bioinformatic analysis to evaluate the relationship between 283 BP-associ

SUBMITTER: Liu Y 

PROVIDER: S-EPMC6171279 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature