Association between MPO-463G > A polymorphism and chronic kidney disease: a meta-analysis.

ABSTRACT:

Background/objective

Previous studies have shown that MPO -463G > A (rs2333227) might be associated with chronic kidney disease (CKD) susceptibility, but sample sizes of those studies are relatively small. Hence, we decided to perform a meta-analysis to evaluate the association. Methods/main results: Two investigators search databases systematically and independently. Odds ratios and 95% confidence intervals were used to pool the effect size. Four articles with 618 cases and 932 controls in total were included in our meta-analysis.

Conclusions

MPO -463G > A was not associated with CKD susceptibility in recessive model and homozygote comparison. MPO -463G > A was associated with increased risk of CKD in allelic comparison, heterozygote comparison and dominant model, however,

SUBMITTER: Qin J 

PROVIDER: S-EPMC6171445 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature