Fabrication of Microchannels and Evaluation of Guided Vascularization in Biomimetic Hydrogels.

ABSTRACT:

Background

The fabrication of microchannels in hydrogel can facilitate the perfusion of nutrients and oxygen, which leads to guidance cues for vasculogenesis. Microchannel patterning in biomimetic hydrogels is a challenging issue for tissue regeneration because of the inherent low formability of hydrogels in a complex configuration. We fabricated microchannels using wire network molding and immobilized the angiogenic factors in the hydrogel and evaluated the vasculogenesis in vitro and in vivo.

Methods

Microchannels were fabricated in a hyaluronic acid-based biomimetic hydrogel by using "wire network molding" technology. Substance P was immobilized in acrylated hyaluronic acid for angiogenic cues using Michael type addition reaction. In vitro and in v

SUBMITTER: Lee J 

PROVIDER: S-EPMC6171653 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature